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- W2382923956 abstract "Objective To investigate the changes of atrial natriuretic peptide (ANP) and endothelin (ET) in experimental material for diagnosis and treatment in clinical pericarditis.Methods Twenty four rabbits were randomly divided into two groups. Thirteen rabbits in groups I were injected 30 % urea into the pericardial cavity. Groups II rabbits were injected 0.9 % sodium chloride into the pericardial cavity as control.Pre injection and post injection levels of ANP and ET in the serum on days 1, 4, 7, 10, 15 and 21 were measured. On the 21st day after injection, all rabbits were killed. ANP and ET in myocardial tissues were observed under histopathological and electro microscopic sections. The levels of ANP and ET in the serum on days 1 10 after injection were higher than that on pre injection, but on the 21st day after injection, the levels of ANP in the serum were lower than that on pre injection (P0.05). However, there was a sustained increase in the serum concentration of ET and remained at a high level on the 21st day. Cardiac damage was found under histopathological and electron microscopic sections. Conclusions The initial increase in serum concentrations of both ANP and ET suggested cardiac damage, but the cardiac function was in the complementary phase. However, subsequently, the serum concentration of ANP decreased and that of ET a sustained increase, which showed that the heart had more damage and the cardiac function was in an uncomplementary phase." @default.
- W2382923956 created "2016-06-24" @default.
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- W2382923956 date "2002-01-01" @default.
- W2382923956 modified "2023-09-26" @default.
- W2382923956 title "The changes of atrial natriuretic peptide and endothelin in experimental pericarditis and their clinical significance" @default.
- W2382923956 hasPublicationYear "2002" @default.
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