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- W2382924263 abstract "Drug-induced liver injury( DILI) has become an increasingly important entity and a major cause for failures of drug development programs,drug withdrawals from market and use restrictions. Unfortunately,varied clinical manifestations,and lack of a gold diagnostic criterion have made DILI very difficult to manage or cure. By far,available treatment of DILI consists of rapid drug discontinuation and supportive care targeted to alleviate unwanted symptoms. To prevent the progression to liver disease and acute liver failure,early hazard identification,risk assessment and avoidance strategies are essential for scientists to address the gaps in hepatic biomarkers faced during drug development. Although there are no breakthroughs,several novel biomarker candidates have been identified. A brief overview is made on the risk management,pathogenesis,clinical classification,diagnosis,treatment and biomarker of DILI." @default.
- W2382924263 created "2016-06-24" @default.
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- W2382924263 date "2014-01-01" @default.
- W2382924263 modified "2023-09-23" @default.
- W2382924263 title "Drug-induced liver injury: a brief overview" @default.
- W2382924263 hasPublicationYear "2014" @default.
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