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- W2382928126 abstract "Objective To detect the expression of activin receptor-interacting protein 2(ARIP2) in atherosclerotic plaques,investigate the association between ARIP2 and atherosclerotic plaque.To explore the changes of levels of matrix metalloproteinases-9(MMP-9),triglycerides(TG),total cholesterol(TC) and the relationship between MMP-9,TG,TC and atherosclerosis.Methods 16 ApoE-/-mices were randomly divided into two groups:control group(n=8),experimental group(n=8).The control group received normal mouse forage,experimental group was fed with high fat diet.After 8 weeks,serum concentrations of MMP-9,TG and TC were measured.The expression of ARIP2 was detected by immunohistochemical method.The correlation between MMP-9 and ARIP2 was investigated in Pearson correlation coefficient.Results ①In the experimental group,MMP-9,TG and TC were significantly higher than those of control group,MMP-9(405.76±53.82) μg/L vs(335.78±46.57)μg/L,TG(1.54±0.35) mmol/L vs(1.13±0.28) mmol/L,TC(23.72±5.43) mmol/L vs(17.59±4.30) mmol/L(P0.05 or 0.01).②HE staining of aortic arch in mice showed aortic intima slightly thickened and the foam cells rarely in the control group;but in experimental group,there were a large number of foam cells and the cell body increased,cytoplasmic vacuolization.③Immunohistochemical assay showed little expression of ARIP2 in control group,whereas ARIP2 had a obviously positive expression in experimental group.The expression of ARIP2 was significantly different between control and experimental group,as 365.46±132.71 vs 1 536.73±634.92(P0.01).The expression of ARIP2 was correlated significantly with MMP-9 and ARIP2(r=0.853,P0.05).The expression of ARIP2 was correlated significantly with MMP-9.Conclusion ARIP2 has a strong positive expression in atherosclerotic plaques,the expression was positively correlated to the degree of atherosclerotic plaque,suggesting that regulating the level of ARIP2 in atherosclerotic plaques is expected to be a new means of treatment for atherosclerosis." @default.
- W2382928126 created "2016-06-24" @default.
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- W2382928126 date "2011-01-01" @default.
- W2382928126 modified "2023-09-23" @default.
- W2382928126 title "Activin receptor-interacting protein 2 expression in atherosclerotic plaque in ApoE~(-/-)mices" @default.
- W2382928126 hasPublicationYear "2011" @default.
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