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- W2382944440 abstract "OBJECTIVE To study the protective mechanism of water extracts of Red Ginseng on Aβ25-35-induced human neuroblastoma SH-SY5Y cells apoptosis. METHODS SH-SY5Y cells were treated with Aβ25-35.We simulated the pathologic damage in brain of patients with Alzheimer's disease,and different doses of water extracts of Red Ginseng were added.The morphologic changes were observed by inverted microscope. Cell survival rate was measured by MTT assay. The percentage of apoptosis and the changes of mitochondrial membrane potential were measured by flow cytometry. RESULTS After 72 h of Aβ25-35 (50 μmol·L-1) treatment,SH-SY5Y cells became rounder and aggregated. The cell survival rate was 39.26%±3.16%;the percentage of apoptosis was 37.30%±0.69%,and the mitochondrial membrane potential was 0.45±0.10.When incubated with Aβ25-35with different doses of Red Ginseng extract (1,5,10 mg·ml-1) for 72 h,cell damage was obviously decreased.Cells survival rate increased;cell apoptosis decreased,and mitochondrial membrane potential increased as well. CONCLUSION Water extracts of Red Ginseng has remarkable neuroprotective effects on SH-SY5Y cells apoptosis induced by Aβ25-35." @default.
- W2382944440 created "2016-06-24" @default.
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- W2382944440 date "2008-01-01" @default.
- W2382944440 modified "2023-09-26" @default.
- W2382944440 title "Neuroprotective effects of water extracts of Red Ginseng on SH-SY5Y cells apoptosis induced by Aβ_(25-35)" @default.
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