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- W2382968704 abstract "Objective To assess the correlation between glucocorticoid induced femoral head necrosis and the number and function of circulating endothelial progenitor cell (EPC).Methods Twenty-four Sprague-Dawley (SD) rats were divided in 2 groups randomly: model group and control group, 12 rats in each group. Models of the femoral head necrosis were induced by intramuscular injection with dexamethasone 10 mg/kg weekly for 6 weeks. Equivalent phosphate buffered saline (PBS) was used as controls in the corresponding time period. The number and in vitro function of circulating EPC were assessed in each group.Results The number of circulating EPC in the model group was (0.018±0.005)%, and decreased evidently compared to the control group (0.038±0.013)% (t =1.38,P0.01). Meanwhile, the function of circulating EPC including proliferation, adhesion and migration ability in vitro in the model group were all down-regulated compared to the control group (P0.01). Conclusion The occurrence of glucocorticoid induced femoral head necrosis was correlated with the down-regulation of the number and function of circulating EPC." @default.
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- W2382968704 date "2013-01-01" @default.
- W2382968704 modified "2023-09-27" @default.
- W2382968704 title "The research on the status of circulating endothelial progenitor cell in a rat model of glucocorticoid induced femoral head necrosis" @default.
- W2382968704 hasPublicationYear "2013" @default.
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