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- W2382969124 abstract "Resistin is a secreted protein with high level of Cys expressed from mouse white adiposetissue. Recently,many studies show that expression patterns of human and mouse resistin are different.Mouse resistin is primarily expressed in white adipose tissue,whereas human resistin is highly expressedin PBMCs /macrophages and bone marrow. But the cellular localization of the protein in bone marrow isnot clear. In the present study,in order to identify the resistin-expressing cells in bone marrow,wedetected the expression of resistin in bone marrow by immunofluorescence. The result showed that humanresistin was dominantly expressed in mature neutrophils with rod and segment-shaped nuclei,and the expression level was higher in the cells with rod-shaped nuclei than the segment-shaped ones. Anti-hresistin IgG-Biotin-PE stained cells were sorted and analyzed by Wright dye staining. The results showedthat human resistin was primarily stored in neutrophils and less in eosinophils of peripheral WBCs.Moreover,human resistin was present in cytoplasm. RT-qPCR analysis revealed that monocytes andneutrophils were the primary cells of the human peripheral WBCs. In order to confirm the cell type thatexpressed resistin,we detected bone marrow cells and peripheral WBCs expressing both HNL and resistinby two-color fluorescence analysis,and the results indicated that the dominant resistin-expressing cellswere neutrophils. Hence,we conclude that the majority of the resistin-expressing cells in human areneutrophils,which sheds light on the relationship between inflammation and the expression of humanresisitin." @default.
- W2382969124 created "2016-06-24" @default.
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- W2382969124 date "2011-01-01" @default.
- W2382969124 modified "2023-09-25" @default.
- W2382969124 title "Expression of the Human Resistin in Neutrophil" @default.
- W2382969124 hasPublicationYear "2011" @default.
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