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- W2382981333 abstract "Objective: To observe the effects of the therapeutic dose of erythromycin in combination with calcium antagonists on gastrointestinal motion in mice and rabbits Methods: The effects of erythromycin in combination with nifedipine on gastrointestinal motion in mice were studied in vitro The effects of erythromycin alone and in combination with diltiazem on contractile activity of isolated ileal smooth muscle in rabbits were investigated in vitro Results: Erythromycin decreased significantly the velocity of gastric emptying and prochoresis of intestinal contents in mice, and more so in mice which received erythromycin in combination with a large dose of nifedipine In vitro experiment, 5×10 -6 ～5×10 -5 mol·L -1 erythromycin evoked the contractions of ileal smooth muscle in rabbits in a dose dependent manner, and this effect was inhibited absolutely by 10 -5 mol·L -1 diltiazem Conclusion: A therapeutic dose of erythromycin in combination with nifedipine inhibits gastric emptying and prochoresis of intestinal contents in mice in a greater degree than that of erythromycin alone In addition, erythromycin enhances the contractile activity of isolated ileal smooth muscle in rabbits, which may be exerted by increasing the inflow of extracellular calcium" @default.
- W2382981333 created "2016-06-24" @default.
- W2382981333 creator A5091401493 @default.
- W2382981333 date "2003-01-01" @default.
- W2382981333 modified "2023-09-25" @default.
- W2382981333 title "Effects of therapeutic dose of erythromycin in combination with calcium antagonists on gastrointestinal motion in mice and rabbits" @default.
- W2382981333 hasPublicationYear "2003" @default.
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