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- W2382985991 abstract "To investigate the expression of CD40 molecule on colon cancer cell lines and to evaluate the growth-inhibitory effect of recombinant soluble human CD40L (rshCD40L) on colon cell lines,the expression of CD40 on colon cell lines (HCT116,Caco-2,SW48,and COLO-320) and the changes induced by interferon-γ(IFN-γ) were examined by flow cytometry.The growth-inhibitory activity of rshCD40L on colon cancer cell lines was examined by MTT assay and the proportion of apoptotic tumor cells was examined with TUNEL assay. Also,the growth-inhibitory effect of the combined activity of rshCD40L and IFN-γ was examined.As demonstrated by flow cytometry,the CD40 molecules could be detected on 3 strains of colon cancer cell lines (HCT116,Caeo-2 and SW48) and the molecular expression of CD40 on these cell lines could be enhanced by the action of IFN-γ.However,the proliferative activities of these cell lines were markedly inhibited by rshCD40L molecule with the growth-inhibitory activities of 33.5±5.5% for HCT116;21.5±3.6% for Caco-2 and 30.1±4.2% for SW48 cell lines respectively. Nevertheless,no apoptosis-induced effect could be detected in another CD40+colon cancer cell line COLO320 (P0.05).In addition,IFN-γ could significantly enhance the activities of proliferation inhibition and induction of apoptosis. From these observations,it is evident that the combined activity of rshCD40L and IFN-γ inhibit proliferation and induce apoptosis of the CD40+colon cancer cell line,and thus has a potential anti-tumor effect." @default.
- W2382985991 created "2016-06-24" @default.
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- W2382985991 date "2010-01-01" @default.
- W2382985991 modified "2023-09-28" @default.
- W2382985991 title "The growth-inhibitory activity of CD40 ligand in colon cancer in vitro" @default.
- W2382985991 hasPublicationYear "2010" @default.
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