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- W2382989495 abstract "Objective To investigate the protective role of FDP to STZ induced islest apoptosis and the potential mechanisms.Methods The pancreases of the rats were treated to collect islets cells.The cells were incubated with STZ with/or FDP.Cell morphology,insulin secretion,HO-1 activity,CO content,SOD activity,GSH-px activity,iNOS activity were examined.No conetent and apoptotic percentage was detected.Results HO-1 activity and CO content of the normal control group were low.STZ induced a significant decrease of cell activity and insulin release,flow cytometry analysis showed that apoptotic percentage of islet cells remarkably increased following the addition of STZ,FDP obviously improved the islets cellular activity damaged by STZ,basic amount of insulin secretion and stimulated by high glucose were improved(P0.01).Content of CO,activity of HO-1,SOD activity,GSH-PX activity were lower in the STZ group than the normal control group(P0.01).The conetent were significantly higherin the STZ group than in the FDP group.Activities of HO-1 and content of CO were higher than in the STZ group.Conclusion FDP can alleviate STZ induced apoptosis of cultured β cells.the mechanism may be the improved HO-1 activity and increased CO content,improved SOD activity,GSH-px activity and decreased iNOS activity and NO content." @default.
- W2382989495 created "2016-06-24" @default.
- W2382989495 creator A5052886909 @default.
- W2382989495 date "2009-01-01" @default.
- W2382989495 modified "2023-09-24" @default.
- W2382989495 title "Mechanism of alleviation of STZ induced pancreatic islets apoptosis by fructose-1,6-disphosphate" @default.
- W2382989495 hasPublicationYear "2009" @default.
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