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- W2383017229 abstract "Objective To explore and compare two methods for establishing an animal model of experimental acute sinusitis in rabbits.Methods Forty-two specific pathogen-free adult male New Zealand white rabbits were divided into three groups.In group A,the sinusitis were induced by both occluding the sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae(18 rabbits). In group B,animals were treated by both insertion of a piece of synthetic sponge(Merocel~(A○R))into the nasal cavity and instillation of Streptococcus pneumoniae into the nose(18 rabbits).The animals in group C received no treatment(6 rabbits).Each six animals were sacrificed at the time points of 1,2,and 3 weeks after the treatment in both group A and group B,six animals in blank control group were killed at 1 week after the treatment.The maxillary and ethmoid sinuses were opened up to take secretion samples for bacteriological culture according to aseptic techniques.At the same time,the maxillary sinuses and ethmoid sinuses were removed en bloc for whole-mount histologic examination.Results The differences of bacterial infection with the primary and opportunistic pathogens between group A and group B were insignificant(P0.05).According to histopathological examination,both methods were proven highly reliable,producing purulent sinusitis in virtually 100% of animals.Acute ethmoid sinusitis was successfully induced in the rabbits of group B.The histopathological changes in maxillary sinus mucosa in group B were lighter in degree than those in group A(P0.05).Conclusion The method of inserting a synthetic sponge into the nasal cavity and intranasal Streptococcus pneumoniae inoculation can be used to establish a stable acute sinusitis model in rabbits,which is closely resembling the human condition,and may become a simple,viable and perhaps preferable animal model." @default.
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- W2383017229 date "2007-01-01" @default.
- W2383017229 modified "2023-09-28" @default.
- W2383017229 title "Comparison of Two Methods for Establishing a Model of Experimental Acute Sinusitis in Rabbits" @default.
- W2383017229 hasPublicationYear "2007" @default.
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