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- W2383040663 abstract "AIM:To study the effects of airway and pulmonary inflammation on pulmonary arterial remodeling in rats with chronic bronchitis(CB)and emphysema.METHODS:Twenty-four male Wistar rats were divided into three groups(n=8):Group A:four-weeks CB and emphysema;Group B:six-weeks CB and emphysema group;Group C:normal control.The rat model of CB and emphysema was established by intratracheal instillation of lipopolysaccharide(LPS)and daily exposure to cigarette smog.The arterial blood gas analysis,pulmonary hemodynamics changes and cell counts in bronchoalveolar lavage fluid(BALF)were measured.The pathomorphological changes of airway inflammation,alveoli destruction and pulmonary arterial remodeling were observed by HE straining and triple straining.RESULTS:(1)The characteristic pathological changes of CB and emphysema were observed in group A and B.Neutrophils were the main cells infiltrated into the walls of airway in group A.Lymphocytes and macrophages were the main cells in group B.(2)Right ventricular systolic pressure(RVSP),mean pulmonary arterial pressure(mPAP),the ratio of the weight of right ventricle/left ventricle and septum(RV/LV+S)in group A and B were significantly higher than those in group C(P0.05).The amount of muscular artery(MA)in group A and B were significantly higher than that in group C(P0.05).(3)In group A and B,the levels of MA,RVSP,mPAP and RV/LV+S was correlated positively with the average alveolar area,the total cell counts and differential cell counts of neutrophils,lymphocytes and macrophages in BALF,and the level of infiltration into the walls of airway,respectively(P0.05).The positive correlation was observed with the percentage of neutrophils,lymphocytes and macrophages between group A and B(P0.05).The amounts of MA were also correlated positively with RVSP,mPAP and RV/LV+S(P0.05).CONCLUSIONS:(1)The pulmonary artery hypertension,the right ventricular hypertrophy and the pulmonary arterial remodeling appeared before hypoxia.These may be related with the degree of the pulmonary inflammation.(2)The characteristic of pulmonary arterial remodeling was small artery organization,and correlated positively with the changes of hemodynamics." @default.
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- W2383040663 date "2006-01-01" @default.
- W2383040663 modified "2023-09-26" @default.
- W2383040663 title "Relationship between airway inflammation and pulmonary arterial remodeling in rats with chronic bronchitis and emphysema" @default.
- W2383040663 hasPublicationYear "2006" @default.
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