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- W2383046355 abstract "Objective This study was designed to study the effects of long-term low dosage hormone replacement therapy on the hormone level and peripheral Benzodiazepine receptors (PBR) of post-menopausal women.Methods 83 women with long-term low dose HRT for over 4 years entered the study, 99 people with age and education matched were enrolled in this study as control. All the subjects were from the personnel of Peking Union Hospital. Plasma estradiol, testosterone and progesterone were analyzed with ELISA. The binding activities of peripheral blood PBR were analyzed with isotope labeling method.Results Compared with the control group, there was a significant increase in the level of estradiol (P0.05) in the subjects with different ages and no difference in the level of progesterone and testosterone of postmenopausal women using HRT. Additionally, postmenopausal women using HRT displayed a higher binding capacity of PBR. A significant difference was found between the 50~59 age stage and control group (P0.01). Meanwhile, the binding capacity of PBR was significantly correlated with plasma estradiol level.Conclusion These results suggest that long-term low dose HRT could maintain estradiol and PBR binding at higher levels." @default.
- W2383046355 created "2016-06-24" @default.
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- W2383046355 date "2007-01-01" @default.
- W2383046355 modified "2023-09-24" @default.
- W2383046355 title "Effects of Long-term Low Dosage Hormone Replacement Therapy on the Peripheral Benzodiazepine Receptors (PBR) of Post-menopausal Women" @default.
- W2383046355 hasPublicationYear "2007" @default.
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