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- W2383048645 abstract "Objective:To compare the effects of 3 different crystalloid fluids at different osmotic concentrations on blood-brain barrier(BBB) and brain edema in severe hemorrhagic shock rats.Methods: A total of 150 male SD rats were equally randomized into a lactated Ringers(LR) group,a 7.2% hypertonic saline(HS) group and a plasmalyte A(PA) group.LR,PA and HS were administered after an hour of severe hemorrhagic shock induced by drawing out about 40% of total blood and maintaining MAP at 35-45 mmHg.Serum S100B,cerebra1 Evans Blue(EB) and water content were determined before(T_0) and 1 h after bleeding(T_1) and immediately(T_2),1 h(T_3) and 2 h(T_4) after administration.The changes of BBB in the hippocampus CA1 area were observed by electron microscopy.Results: The serum S100B level was obviously higher at T_1,T_2,T_3 and T_4than at T_0 in all groups(P0.05) and evidently lower s at T_3 and T_4 in the HS and PA than in the LR group(P0.01),with no difference in the EB content among different time points(P0.05).The cerebra1 water content was significantly increased at T_1,T_2,T_3 and T_4in the LR group,at T_1in the HS and at T_1,T_2 and T_3 in the PA as compared with T_0(P0.05),but lower at T_2,T_3 and T_4in the HS and at T_3 and T_4in the PA than in the LR group at the same time point.Electron microscopic studies showed evident changes of BBB after a 1-hour hemorrhagic shock,most obviously the vacuolization of the glia cell foot process and severe brain edema in the LR group.Conclusion: Severe hemorrhagic shock induces BBB injury and cerebral edema,which could be aggravated by LR and alleviated by HS and PA,the former even more effectively than the latter." @default.
- W2383048645 created "2016-06-24" @default.
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- W2383048645 date "2008-01-01" @default.
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- W2383048645 title "Effects of different crystalloid fluids at different osmotic concentrations on blood-brain barrier and cerebral edema in hemorrhagic shock rats" @default.
- W2383048645 hasPublicationYear "2008" @default.
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