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- W2383075032 abstract "AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin 1β (IL 1β) pro osteoclastic activities. METHODS: TdR uptake by osteoblasts was used to measure cell proliferation, microspectrophotometer for cellular AlP activity using p nitrophenyl phosphate as enzyme substrate, and radioimmunoassay for prostaglandin E 2. RESULTS: Quercetin 5-40 μmol·L -1 reduced the inhibition of cell proliferation and AlP activity induced by TNF or IL 1β in a concentration dependent manner. PGE 2 produc￣tion stimulated by either cytokines was also reduced by quercetin at 20 and 40 μmol·L -1 . CONCLUSION: quercetin exerted a marked inhibitory effect on TNF and IL 1 activities, related to their pro osteoclastic function." @default.
- W2383075032 created "2016-06-24" @default.
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- W2383075032 date "1996-01-01" @default.
- W2383075032 modified "2023-09-25" @default.
- W2383075032 title "Inhibitory effect of quercetin on tumor necrosis factor and interleukin 1β" @default.
- W2383075032 hasPublicationYear "1996" @default.
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