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- W2383089666 abstract "Objective To study the MVD and the expression of VEGF,Flt-1 and KDR in Gastric Carcinoma.Methods MVD and the expression of VEGF,Flt-1and KDR were examined by immunohistochemical staining in 208 gastric carcinoma specimens and 139 normal tissues.Results The expression of VEGF,Flt-1 and KDR was significantly higher in gastric carcinoma than in normal tissues(P 0.01).MVD at intratumoral areas was significantly higher than at normal gastric(26.19±16.23 vs 16.02±09.88/mm2,P 0.01).The expression of VEGF,Flt-1 and KDR was correlated with lymph node metastasis and penetrating depth(P 0.05).In the area with high expression of VEGF,there was intensive expression of Flt-1 and KDR.There was significant positive correlation between VEGF,Flt-1,KDR and MVD(P 0.05).Conclusion VEGF,Flt-1 and KDR are widely expressed in GC tissues,and are positively related to pathological features and MVD of GC patients.The expression of VEGF is significantly correlated with Flt-1,KDR.These results suggest that VEGF,Flt-1 and KDR have an important role in angiogengesis and metastasis of gastric carcinoma." @default.
- W2383089666 created "2016-06-24" @default.
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- W2383089666 date "2008-01-01" @default.
- W2383089666 modified "2023-09-27" @default.
- W2383089666 title "Expression of VEGF and its Receptors Flt-1 and KDR in Gastric Carcinoma and its Significance" @default.
- W2383089666 hasPublicationYear "2008" @default.
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