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- W2383092589 abstract "Objective To observe the effect of urinary calculus induced by the Melamine fed on rats per day from 1 day to 30 days.Methods 130 SPF SD rats were randomized into 5 Melamine groups with 20 rats per group,the solvent control group with 10 rats and the blank control group with 20 rats.The rats of the 5 Melamine groups were fed the Melamine with the dosage range of 0.4 g/(kg·d),0.3 g/(kg·d),0.2 g/(kg·d),0.1 g/(kg·d) and 0.05 g/(kg·d),respectively. The rats of the solvent control group were given 2 ml of 10 g/L methylcellulose distilled water by gavage per day.And the rats of the blank control group were given 2 mL of distilled water per day.The morphological changes of kidneys,ureters and bladders on rats were observed by naked eyes and stereomicroscope.The body weight and organs index of each group as well as the level of serum CREA,BUN,UA,Ca,P,Mg were compared.Results The levels of CREA in the medication groups [0.4 g/(kg·d) after medication of melamine for 20 days,0.2 g/(kg·d),0.4 g/(kg·d) after medication for 30 days] were higher than those in the blank control group.The levels of BUN、UA in the 0.4 g/(kg·d) group after medication for 30 days were higher than those in the blank control group.The levels of Ca,P,Mg in 5 medication groups after medication for 20 days were lower than those in the blank control group.The weight of left kidney on rats in 0.05,0.2,0.3,0.4 g/(kg·d) groups after medication for 30 days were higher than those in the blank control group.The shape and colour of kedney in 5 medication groups were normal compared of the blank control group.The urinary calculus and yellow precipitates were not found in kidneys and ureters.But the punctiform and patchy hemorrhagic focus were odserved in some kidneys between cortex and medulla.Some congestion in the mucosa of bladder was found.The bladder calculus induced by the melamine were found in some male rats and the appearance rate was 52%(13/25)on 20th days as well as 56%(14/25)on 30 th days in 5 Melamine groups.The colour of the bladder calculus was yellow-white or white.Conclusions The male rats were fed the melamine with the dosage range of(0.05～0.4)g/(kg·d) for 30 days.Some male rats appearance the bladder calculus and the damage in kedneys were slight." @default.
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- W2383092589 date "2009-01-01" @default.
- W2383092589 modified "2023-09-26" @default.
- W2383092589 title "Research on Urinary Calculus Models on Rats Induced by the Melamine" @default.
- W2383092589 hasPublicationYear "2009" @default.
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