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- W23831330 abstract "Increasing evidence shows the presence and significance of CD8+ T regulatory cells (CD8+ Tregs) in both human and rodent transplant recipients, as well as in autoimmune disease models. We, hereafter, review all available data on the phenotypic and functional characterization of CD8+ Tregs, and we also provide detailed protocols to purify them and analyze their suppressive function. Different subsets of dendritic cells (DCs) and CD4+ effector T cells may modulate the suppression mediated by CD8+ Tregs. By analyzing the proliferation of CFSE-labeled naïve CD4+CD25- T cells in coculture MLR and transwell experiments, we explored the mutual modulation of CD8+ Tregs, DC subsets, and CD4+ T effector cells. The suppressive function of CD8+ Tregs was mediated by both cell-contact-dependent and -independent mechanisms." @default.
- W23831330 created "2016-06-24" @default.
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- W23831330 date "2010-01-01" @default.
- W23831330 modified "2023-10-18" @default.
- W23831330 title "Phenotypic and Functional Characterization of CD8+ T Regulatory Cells" @default.
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- W23831330 doi "https://doi.org/10.1007/978-1-60761-869-0_5" @default.
- W23831330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20941603" @default.
- W23831330 hasPublicationYear "2010" @default.
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