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- W2383137690 abstract "PURPOSE:To study the clinical significance of osteopontin(OPN)expression in oral squamous cell carcinoma(OSCC).METHODS:OPN expression was examined in OSCC and normal oral mucosa(NOM)by the method of En VisionTM and fluorescence quantitative real-time PCR,the staining-grade was quantitatively studied by multiple functional image analyzer.OPN expression grade of different clinical and pathological index was statistically evaluated using SPSS11.5 software package.RESULTS:OPN expression grade was significantly higher in OSCC than that in NOM in both the mRNA level and protein level(P0.05);significant difference of OPN expression grade was found between the different clinical stages,as well as between the groups with or without cervical lymph node metastasis.The group with cervical lymph node metastasis(n=20)had higher expression than that of the group without lymph node metastasis(n=39,P0.05).However,there was no significant difference between the expression grade in well-differentiated(n=38)group and moderate or poorly differentiated group(n=21).CONCLUSION:OPN overexpression is found in OSCC,and the expression level correlates with the clinical staging and cervical lymph node metastasis." @default.
- W2383137690 created "2016-06-24" @default.
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- W2383137690 date "2007-01-01" @default.
- W2383137690 modified "2023-09-27" @default.
- W2383137690 title "Quantitative analysis and significance of osteopontin expression in oral squamous cell carcinoma" @default.
- W2383137690 hasPublicationYear "2007" @default.
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