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- W2383141338 abstract "Objective To study the efficacy-enhancing and toxicity-reducing effects of soybean polysaccharides on cyclophosphamide in S180 tumor-bearing mice and the mechanisms.Methods 80 Kunming mice were inoculated 0.2 ml per mouse of S180 sarcoma cell suspension in armpit and then randomized into 8 groups: blank control group(treated with saline),3 soybean polysaccharides(SSPS) groups(treated with 50,100 and 200 mg/(kg·d) of SSPS respectively),cyclophosphamide(CP) group(treated with 25 mg/(kg·d) of CP),and 3 combination groups(treated with(1) CP 25 mg/(kg·d) + SSPS mg/(kg·d),(2) CP 25 mg/(kg·d) + SSPS 100 mg/(kg·d),and(3) CP 25 mg/(kg·d) + SSPS 200 mg/(kg·d),respectively).Drugs were given at a dose of 0.2 ml per mouse for 10 days.The tumor weight,thymus and spleen indice were measured;ELISA was used to determine the IL-2 content.Results SSPS had inhibited the tumor growth;the inhibitory rates of the 3 SSPS groups were 24.10%,35.39% and 39.75% respectively.While in the combination groups,the inhibitory rates were 89.87%,91.91% and 92.63% respectively(P0.05,P0.01) with q value of 0.99-1.00,suggesting a synergistic effect.In addition,the thymus and spleen indice were increased and the IL-2 secreation promoted in the combination groups.Conclusion SSPS can enhance the anti-tumor effect of cyclophosphamide by regulating the immune function of tumor-bearing mice while reducing the toxicities of cyclophosphamide." @default.
- W2383141338 created "2016-06-24" @default.
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- W2383141338 date "2013-01-01" @default.
- W2383141338 modified "2023-09-23" @default.
- W2383141338 title "Synergistic antitumor effect of soybean polysaccharides combined with cyclophosphamide in S_(180) tumor-bearing mice" @default.
- W2383141338 hasPublicationYear "2013" @default.
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