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- W2383185525 abstract "Objective:To study the toxicity and radiosensitizing effect of semi-artificial synthic chiral docetaxel on human lung adenocarcinoma cell line A549.Methods:The chiral docetaxel was synthesized chemically.Inhibition effect of docetaxel on the growth of A549 was determined by MTT assay.The differences of morphology changes were observed by inverted fluoresence microscope.The A549 cells and mouse-beared tumor were treated with chemically synthesized docetaxel and the inhibitory effects on A549 cells were observed.Results:There were significent differences of inhibition rate among different docetaxel concerntrations and time.Treatment of docetaxel and radiation caused A549 cells G_2/M block.The xenograft subcutaneous lung cancer cell line A549 of nude mice was successfully reduced by docetaxel.And the volumes of transplantive tumor in control group,docetaxel group,radiation group and docetaxel combined radiation group were(7 780±1 050)mm3,(4 610±950)mm3,(5 540±1 035)mm3 and(560±112.5)mm3,respectively.Conclusion:Semi-artificial synthetic chiral docetaxel had significantly radiosensitizing effect and toxicity on A549 cells." @default.
- W2383185525 created "2016-06-24" @default.
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- W2383185525 date "2008-01-01" @default.
- W2383185525 modified "2023-09-23" @default.
- W2383185525 title "Study of toxicity and radiosensitizing effect of semi-artificial synthetic chiral docetaxel on human lung adenocarcinoma cell line A549" @default.
- W2383185525 hasPublicationYear "2008" @default.
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