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- W2383206229 abstract "Objective To investigate the effect of Zebularine and sodium butyrate on cell growth,apoptosis and expression of P16 mRNA in human colon cancer cell line LOVO.Methods Human colon cancer cell lines LOVO were cultured and divided into Zebularine group,sodium butyrate group,Zebularine+sodium butyrate group and control group.The cell growth rate was detected by MTT assay after 24 h,48 h,72 h of culture.The cell apoptosis was analyzed by Annexin V-FITC/PI double staining.The expression of P16 mRNA was determined by reverse transcriptase polymerase chain reaction(RT-PCR).Results The cell growth inhibition rate and cell apoptosis rate significantly increased in Zebularine group and sodium butyrate group(P0.05) compared with control group,and the cell growth inhibition rate and cell apoptosis rate of the Zebularine+ sodium butyrate group significantly increased compared with the Zebularine group and sodium butyrate group(P0.05).The relative expression of P16 mRNA of the Zebularine group and sodium butyrate group increased compared with the control,and the relative expression of P16 mRNA of the Zebularne+ sodium butyrate group significantly increased compared with Zebularine group and sodium butyrate group(P0.05).Conclusion Compared with separate application of Zebularine or sodium butyrate,joint application could increase the expression of P16 mRNA and inhibit the growth of cell line LOVO." @default.
- W2383206229 created "2016-06-24" @default.
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- W2383206229 date "2012-01-01" @default.
- W2383206229 modified "2023-09-25" @default.
- W2383206229 title "Effects of Zebularine and sodium butyrate on cell growth,apoptosis and expression of P16 mRNA in human colon cancer cell line LOVO" @default.
- W2383206229 hasPublicationYear "2012" @default.
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