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- W2383209045 abstract "To evaluate the growth-inhibiting and pro-apoptotic effect of kaempferol in human esophageal squamous carcinoma Eca-109 cells and explore the mechanism.The effect of kaempferol on Eca-109 cell proliferation in vitro was measured by MTT assay. TUNEL staining was used to detect the cell apoptosis following kaempferol treatment. The changes in Bax and Bcl-2 mRNA expressions in response to kaempferol treatment were determined by RT-PCR, and the caspase-3 and caspase-9 activities were evaluated using colorimetric assay.Kaempferol significantly inhibited Eca-109 cell proliferation (P<0.05) in a concentration-dependent manner and induced obvious cell apoptosis. RT-PCR showed that after kaempferol treatment caused up-regulated Bax and down-regulated Bcl-2 mRNA expression. The colorimetric assay revealed significantly increased caspase-3 and caspase-9 activities in Eca-109 cells following kaempferol treatment (P<0.01).Kaempferol can induce apoptosis of Eca-109 cells via a mitochondria-dependent pathway." @default.
- W2383209045 created "2016-06-24" @default.
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- W2383209045 date "2011-08-01" @default.
- W2383209045 modified "2023-09-27" @default.
- W2383209045 title "[Kaempferol-induced apoptosis of human esophageal squamous carcinoma Eca-109 cells and the mechanism]." @default.
- W2383209045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21868342" @default.
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