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- W2383230134 abstract "Aim To increase the specificity and affi nity of a humanized mouse ScFv specific against human cross -linked fibrin.Methods Based on the sequence of the humanized ScFv,the partially randomized primers were synthesised and the Mixed HCDR3and LCDR3library was con-structed by using PCR method with partially randomized primers.The library was panned with coated antig en D -dimer,and the bioactivity of ScFv was analysed with ScFv -alkalin e phosphatase detection system which was established in our laboratory.Results Four different human-ized ScFv with better affinity and sp ecifity were identified.Conclusion Constructing the CDR3library is an e ffective way to increase the affinity and specifity of antibody." @default.
- W2383230134 created "2016-06-24" @default.
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- W2383230134 date "2001-01-01" @default.
- W2383230134 modified "2023-09-28" @default.
- W2383230134 title "In vitro maturation of a humanized mouse ScFv specific against human cross-linked fibrin" @default.
- W2383230134 hasPublicationYear "2001" @default.
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