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- W2383243670 abstract "Objective:To investigate the effect of human chorionic gonadotrophin (hCG) on the gene expression of migration inhibitory factor (MIF) in human peripheral blood mononuclear cell (PBMC). Methods:The healthy human PBMC was cultured with hCG at 37 ℃,5%CO2 for 2 hours. The mRNA of harvested cells was isolated. The MIF mRNA was detected by real-time RT-PCR. Results:In a certain range of doses,the mRNA expression of MIF significantly increased following the increase of hCG in a dose depandent manner,and it reached to a peak 1-2 hours after culture,then returned to the minimum level after 8 hours. Conclusion:In a certain range of doses,hCG can increase the mRNA expression of MIF. This effect is correlated with reacting time. It is suggested that hCG may involve in immune response by up-regulating the production of cytokines by PBMC." @default.
- W2383243670 created "2016-06-24" @default.
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- W2383243670 date "2010-01-01" @default.
- W2383243670 modified "2023-09-23" @default.
- W2383243670 title "Effect of Human Chorionic Gonadotrophin on mRNA Expression of Human PBMC MIF" @default.
- W2383243670 hasPublicationYear "2010" @default.
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