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- W2383262640 abstract "Objective:To compare the anti-aging effects of ginsenosides,tanshinone and chuanxionyzine on the skin of D-galactose-induced mice aging model.Methods: One hundred female mice were randomly divided into 5 groups(n=20).Mice in normal control group received subcutaneous injection of normal saline and mice in other 4 groups received cervicodorsal injection of D-galactose(1 000 mg·kg~(-1)·d~(-1)) for 42 d to establish subacute aging model.The experimental groups included aging model group(without further treatment),tanshinone-treated(1 500 mg·kg~(-1)·d~(-1)) group,chuanxionyzine-treated(150 mg·kg~(-1)·d~(-1)) group,and ginsenosides-treated(100 mg·kg~(-1)·d~(-1)) group.Forty-two days later,the dorsal skin samples were collected to determine SOD,CAT activities and MDA,hydroxyproline contents.Results: In tanshinone-and ginsenosides-treated groups,SOD activities increased from(131.2±21.5) U/ml to(203.1±11.2) U/ml and(196.8±27.5) U/ml,respectively;the contents of hydroxyprolin increased from(0.57±0.13) mg/g to(0.71±0.11) mg/g and(0.76±0.12) mg/g,respectively;and the contents of MDA decreased from(9.39±1.5) nmol/g to(6.4±1.3) nmol/g and(7.16±2.3) nmol/g,respectively(all P0.05).However,there was no significant difference between the parameters of tanshinone-and ginsenosides-treated groups.Compared with aging control group,there was no obvious changes in the above parameters in chuanxionyzine-treated group.Conclusion: Both ginsenosides [100 mg/(kg·d)] and tanshinone [1 500 mg/(kg·d)] have noticeable anti-skin aging effects via i.g.administration through improving the activities of antioxidant enzyme and dermal fibroblasts.Chuanxionyzine [150 mg/(kg·d)] shows no anti-skin aging effects in mouse aging models." @default.
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- W2383262640 date "2006-01-01" @default.
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- W2383262640 title "Anti-aging effects of ginsenosides,tanshinone and chuanxionyzine on mice skin: a comparison study" @default.
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