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- W2383265362 abstract "Objective To investigate the effect of calcineurin(CaN)on the superantigne activity of staphylococcal enterotoxin C2(SEC2).Methods Splenic lymphocytes of SD rats were stimulated with recombinant wild SEC2(rSEC2) and its enhanced mutant(mSEC2)(T20L / G22E / H118A / H122A),at various final concentrations(0.5,1,2,3 and 4 μg / ml),and determined for proliferation level by MTT assay.The changes of CaN activity in the course of induction of proliferation of rat lymphocytes with rSEC2 and mSEC2,at a final concentration of 1 μg / ml,were determined,while the effect of various final concentrations(0.1,0.5.1,2 and 3 μg / ml) of cyclosporine A(CsA),a specific inhibitor of CaN,on the course,as well as the changes of three CaN subunits(CaN Aα,CaN Aβ and CaN B)at mRNA level,were evaluated.Results The proliferation index(PI)of rat splenic lymphocytes stimulated with low concentration rSEC2 and mSEC2 was dose-dependent.However,high rSEC2 and mSEC2 concentrations inhibited the proliferation significantly,of which the those at a concentration of 1 μg / ml showed a satisfactory inhibitory effect.CsA showed strong dose-dependent inhibitory effect on the proliferation of rat splenic lymphocytes,of which those at a concentration of 0.5 ～ 1 μg / ml completely inhibited the stimulating effect of rSEC2 and mSEC2.CaN activity as well as CaN Aβ and CaN B mRNA levels were significantly related to the superantigen activity of CaN.Conclusion CaN played an important role in superantigen activity of SEC2,which laid a theoretical basis for enhancing the clinical application and avoiding the adverse reaction of SEC2." @default.
- W2383265362 created "2016-06-24" @default.
- W2383265362 creator A5036761179 @default.
- W2383265362 date "2013-01-01" @default.
- W2383265362 modified "2023-09-26" @default.
- W2383265362 title "Effect of calcineurin on superantigen activity of staphylococcal enterotoxin C2" @default.
- W2383265362 hasPublicationYear "2013" @default.
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