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- W2383278943 abstract "Objective To establish a skin abscess model in nude mice by infection of a clinically isolated methicillin-resistant Staphylococcus aureus(MRSA) strain,and evaluate the dynamics of abscess formation and drug effect.Methods Forty-five specific pathogen free nude mice were randomly divided into three groups: the PBS,MRSA-infected and durg-treated infected groups.All the mice were inoculated by subcutaneous injection of MRSA suspension and the kinetics of abscess formation was monitored.The clinical changes and abscess volume were examined during the whole experimental period.Finally,the abscesses in different groups were examined and compared by histopathological observation using HE staining.Results There were no skin abscess formed in the PBS group during the experimental period.Skin abscesses were observed in the MRSA-infected and drug-treated MRSA-infected groups.The volume of skin abscess was higher in the MRSA-infected mice than that in the drug-treated MRSA-infected animals.Moreover,severe histopathologic changes were observed in the MRSA-infected mice.Conclusion A nude mouse model of skin abscess has been successfully established by MRSA-infection.This model will provide a useful tool for studies on the pathogenic characteristics and pathogenesis of skin abscess caused by MRSA infection,and promote the development of effectivetherapeutic approaches in the future." @default.
- W2383278943 created "2016-06-24" @default.
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- W2383278943 date "2010-01-01" @default.
- W2383278943 modified "2023-09-26" @default.
- W2383278943 title "Establishment and Evaluation of a Mouse Model of Skin Abscess by Infection with an Isolated Methicillin-Resistant Staphylococcus aureus(MRSA) Strain" @default.
- W2383278943 hasPublicationYear "2010" @default.
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