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- W2383301373 abstract "Objective: To observe the influence of As2O3 on sex-ual hormone of male rats. Methods: 32 male rats were allocated to 4 groups randomly, one group served as normal control group, and the other 3 groups were given intraperitoneal injection of various dosage of As2O3 individually. After 2 weeks, the content of serum testosterone (T), follicule - stimulating hormone (FSH), luterotrop-ic hormone (LH), serum arsenic concentration, organ coefficient of testis (OCT) and the count of sperm (CS) were deter-mined. Results: In comparison with normal control group, the serum T of small - dosage group was slightly decreased and markedly de-creased in middle - dosage group ( P0.05, P0.01), Various sosages of As2O3 exerted no influence on FSH and LH. In normal rats, there was a trace of As2O3 in serum, but its concentration was increased by the increase of As2O3 injection. Various dosages of As2O3 exerted no influence on OCT, but the CS was decreased bythe increase of As2O3 injection and more markedly in largedosage group (P0.01) as compared with normal control group. The relation of serum As2O3 with serum T and SC showed a linear negative correlation (r=0.489 and -0.515, P0.01); the rela- tion of serum Tand CS showed a linear positive correlation (r= 0.351, P0.05) . Conclusion: As2O3 acls through the injury of testis tissue to inhibit the secretion of T in rats so as to reduce the generation of sperm and produce male reproductive toxicity." @default.
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- W2383301373 date "2004-01-01" @default.
- W2383301373 modified "2023-09-25" @default.
- W2383301373 title "The Influence of Arsenic Trioxide on the Sexual Hormone of Male Rats" @default.
- W2383301373 hasPublicationYear "2004" @default.
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