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- W2383310317 abstract "Objective To explore the expression level of calmodulin (CaM) in non-small cell lung carcinoma (NSCLC) and its clinical significance. Methods The expression levels of CaM and CaM mRNA were detected in 64 human NSCLC samples by immunohistochemistry and in situ hybridization, respectively. Results The positive rates of CaM mRNA and CaM protein were 60.4% and 65.6%, respectively. The positive rates of CaM mRNA in low-differentiated samples were significantly higher (70.0%) than those in moderate- to well-differentiated samples (45.3%). The expression rates of CaM in Ⅲ-Ⅳ stages (81.8%) were significantly higher than those inⅠ-Ⅱstages (51.6%) (P0.05). The expression rate of CaM in lymph node metastasis (64.0%) was significantly higher than that in non-lymph node metastasis (28.0%) (P0.05). The positive expression of CaM was not associated with sex and age of patients and the different tissue types of NSCLC. Conclusion High expression of CaM exists in NSCLC and it may be associated with cell differentiation and tumor-node-metastasis (TNM) stages and lymph node status of tumor. The results suggest that high expression of CaM may play an important role in the invasion and metastasis of lung cancer." @default.
- W2383310317 created "2016-06-24" @default.
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- W2383310317 date "2005-01-01" @default.
- W2383310317 modified "2023-09-23" @default.
- W2383310317 title "Expression of calmodulin and its clinical significance in non-small cell lung cancer" @default.
- W2383310317 hasPublicationYear "2005" @default.
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