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- W2383311025 abstract "Aim: To investigate the clinical manifestations, therapy, and prognosis of APS with central nervous system (CNS) impairment, a case of antiphospholipid antibody syndrome (APS) with cephalagra, vertigo, ambulation difficulty, and cognition impairment according to the literature was analyzed. Methods: Analytic study was performed on the clinical features, neuroimaging, laboratory test, pathology, and treatment of one APS patient according to the literature. Results: The main clinical manifestation of APS with CNS impairment were characterized by ischemic stroke or transient ischemic attack, or cerebral venous thrombosis,but APS may manifest as cognitive disorders and so on. The diagnosis criteria for APS is that any kind of antiphospholipid antibodies including anticardiolipid antibody, lupus anticoagulant, and anti-b2-glycoprotein I antibody were positive twice respectively with the interval of at least 12 weeks. This case belongs to microangiopathy type of CNS in APS. Antiplatelet therapy should be the mainstay as the primary prevention, while anticoagulant therapy is the secondary prevention for APS. Conclusion: According to the clinical manifestations of APS and the appearance of antiphospholipid antibodies, the diagnosis of APS with CNS impairment can be attained. It is important to test the three kinds of antiphospholipid antibodies at the same time to enhance the positive rate of diagnosis for APS." @default.
- W2383311025 created "2016-06-24" @default.
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- W2383311025 date "2011-01-01" @default.
- W2383311025 modified "2023-09-28" @default.
- W2383311025 title "Case Report of Antiphospholipid Antibody Syndrome and Literature Review" @default.
- W2383311025 hasPublicationYear "2011" @default.
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