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- W2383312358 abstract "Objective:To evaluate the synergism of recombinant Bacillus Calmette-Guerin (BCG) encoding human granulysin and murine IL-12 to anti-tuberculosis chemotherapy in murine M.tuberculosis infection.Methods:BALB/c mice were infected with M.tuberculosis and were injected with normal saline,recombinant BCG,INH(Isoniazid)+PZA(pyrazinamide),recombinant BCG + INH+PZA respectively.The numbers of viable bacteria in lungs and spleens were counted.The levels of IL-12 and IFN-γ in serum and IFN-γ and TNF-α released from spleen lymphocytes stimulated with PPD were detected with ELISA.The expression of GLS in tissue was detected with immunohistochemistry.Lungs and spleens were prepared for pathological analysis.Results:The recombinant BCG group(4.248±0.414 in lung,3.538±0.563 in spleen),INH+PZA group(3.702±0.438 in lung,3.320±0.358 in spleen),and recombinant BCG + INH+PZA group (3.258±0.250 in lung,2.011±0.103 in spleen)showed significantly reduced number of colony forming units(log CFU/g)compared with saline group.The expression of GLS in tissue and the increased of IL-12 and IFN-γ in serum were found in recombinant BCG group.IFN-γ and TNF-α released from spleen lymphocytes stimulated with PPD in recombinant BCG group were higher than that of other groups(P0.01).The pathological changes in lungs of the recombinant BCG group,INH+PZA group,and recombinant BCG +INH+PZA group were localized,while was spread in the control group.The significant pathological changes were not found in the spleens of all groups.Conclusion:The recombinant BCG has immunotherapeutic effects,the recombinant BCG has a synergism to anti-tuberculosis chemotherapy." @default.
- W2383312358 created "2016-06-24" @default.
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- W2383312358 date "2008-01-01" @default.
- W2383312358 modified "2023-09-25" @default.
- W2383312358 title "Evaluation synergism of GLS/IL-12 recombinant BCG to anti-tuberculosis chemotherapy in murine model of M.tuberculosis infection" @default.
- W2383312358 hasPublicationYear "2008" @default.
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