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- W2383315951 abstract "Objective To observe the pathological changes of heart,liver,spleen and intestines in rats with chronic obstructive pulmonary disease(COPD),and influence of Chinese medicinal with action of diffusing lung,and to lay a foundation for the study on TCM theory of lung associating with large intestine.Methods The rat model of COPD was established by using intratracheal drip transfusion of LPS and cigarette smoking.The pathological changes of heart,liver,spleen,lung,kidney,intestines,testis and bladder were observed.The content of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in bronchoalveolar lavage fluid(BALF),gastric emptying,expressions of IFN-γ mRNA and IL-10 mRNA in intestine tissue and intervention effect of Chinese medicinal were detected and observed.Results In the model group,lesion and partial exuviation of bronchiolar epithetium,adveolar disorder and interstitial thickening,infiltration of a large number of inflammatory cells and consolidation of partial alveoli were observed.The content of TNF-α and IL-1β and lymphocyte count increased significantly.The arrangement of colonic mucous glands was irregular and non-compact,lymphocytes increased,gastric emptying decreased,the expression of colonic IFN-γ mRNA increased,and expression of IL-10 mRNA decreased.There were no obvious pathological changes observed in heart,liver and spleen.After the intervention of Chinese medicinal with the action of diffusing lung,the pathological changes were alleviated in lung,lymphocyte count and the content of TNF-α and IL-1β in BALF decreased significantly.At the same time,the pathological changes were alleviated in colon,gastric emptying was improved,expression of IFN-γ mRNA decreased and expression of IL-10 mRNA increased in colonic homogenate.Conclusion The model of COPD has specific pathological changes in intestines.The administration of Chinese medicinal with the action of diffusing lung can alleviate the pathological changes in lung and intestines,which proves TCM theory of lung associating with large intestine,and the correlation and phenomenon of interactive regulation between lung and intestines." @default.
- W2383315951 created "2016-06-24" @default.
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- W2383315951 date "2011-01-01" @default.
- W2383315951 modified "2023-09-28" @default.
- W2383315951 title "Pathological changes of multi-organs in rat model of chronic obstructive pulmonary disease and intervention of Chinese medicinal with action of diffusing lung" @default.
- W2383315951 hasPublicationYear "2011" @default.
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