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- W2383323250 abstract "Objective To explore the effects of different doses of folic acid on plasma homocysteine levels and cognitive function in the elderly patients with cerebral infarction. Methods 165 elderly patients with lacunar cerebral infarction from Department of Neurology of Nanjing Governmental Hospital,were randomly divided into 3 groups,55 cases in each group. Group A was treated with 5mg / d of folic acid,group B treated with 10mg / d,and group C did not receive the treatment of folic acid. The patients were all given regular treatment for ischemic stroke. Plasma homocysteine was measured at the time of admission and 8 weeks after the treatment. The cognitive function was also evaluated by the Mini-Mental State Examination( MMSE) scale. Results After 8 weeks' treatment,the plasma level of homocysteine was significantly decreased in groups A and B( P 0. 05). Meanwhile,the plasma level of homocysteine in groups A and B was significantly lower than that in group C( P 0. 05),but there was no significant difference between groups A and B( P 0. 05). The MMSE scores were improved obviously in 3 groups 8 weeks after treatment( P 0. 05). The improvement of MMSE scores in groups A and B were significantly higher than that in group C( P 0. 05),but there was no difference between group A and B( P 0. 05). Conclusions The treatment of folic acid can reduce the level of plasma homocysteine and improve cognitive function in the elderly patients with cerebral infarction. The decreased degree of the homocysteine and improved MMSEs have no relationship with the dose of folic acid." @default.
- W2383323250 created "2016-06-24" @default.
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- W2383323250 date "2013-01-01" @default.
- W2383323250 modified "2023-09-25" @default.
- W2383323250 title "Effects of different doses of folic acid on plasma homocysteine levels and cognitive function in the elderly patients with cerebral infarction" @default.
- W2383323250 hasPublicationYear "2013" @default.
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