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- W2383325607 abstract "The objective of this study is to formulate Pluronic lecithin organogel of lornoxicam and evaluate its suitability for topical application. This is an attempt to explore the suitability of lornoxicam for transdermal drug delivery and potential of Pluronic lecithin organogels for topical delivery of lornoxicam. Ten formulations were developed (code of formulation F-1 to F- 10) using lornoxicam, Pluronic F-127, lecithin, isopropyl myristate, water, sorbic acid and potassium sorbate. All the formulation, were prepared by altering the quantity of Pluronic F-127 and lecithin. The formulated organogels were evaluated for appearance, texture, in vitro diffusion study, drug content, viscosity, spreadability and pH. The in vitro drug realease study w as monitored via egg membrane in phosphate buffer (pH 7.4) using modified Keshary-Chein diffusion cell. The viscosities and pH of different formulation were determined by brookfield viscometer and digital pH meter respectively. From the evaluation study it may be concluded that formulation F-2, containing 3% lecithin and 20% pluronic is an effective formulation for transdermal delivery of lornoxicam as it showed satisfactory pH, viscosity, spreadability, drug content and high % cummulative percent drug release (which is 90.13 %). Lornoxicam is a potential candidate for Transdermal delivery and Pluronic lecithin organogel showed satisfactory Transdermal permeation." @default.
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- W2383325607 date "2011-01-01" @default.
- W2383325607 modified "2023-09-27" @default.
- W2383325607 title "Transdermal Delivery of Lornoxicam from Pluronic Lecithin Organogel" @default.
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