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- W2383336334 abstract "Objective To investigate the effects of varied doses of angiotensin Ⅱ receptor antagonist(ARB) valsartan on intrarenal AngⅡ,ET and TGF-β1 in diabetic rats to explore the protective mechanism of ARB.Methods Streptozotocin-induced diabetic Sprague-Dawley rats were divided into an untreated control group,a group treated with smaller-dose valsartan and a group with bigger-dose valsartan, along with normal control group set up with healthy rats.The protein expression of TGF-β1 was determined by immunohistochemistry and the concentrations of AngⅡand ET were determined by radioimmunoassay in the 9th week.Results The expressions of TGF-β1,AngⅡ and ET were higher in the untreated diabetic group than those in the normal control group(P0.01).The concentrations of AngⅡ and ET were decreased(P0.01),but the expression of TGF-β1 was increased(P0.05) in the group treated with bigger dose of valsartan,compared to that with smaller dose.Conclusion The renoprotective effect of bigger-dose valsartan is superior to that of the smaller-dose in DM rats.However,higher expression of TGF-β1 in the group treated with bigger doses suggests that the renoprotective effect of ARB is not complete and may be associated with the activation of TGF-β1 expression." @default.
- W2383336334 created "2016-06-24" @default.
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- W2383336334 date "2007-01-01" @default.
- W2383336334 modified "2023-09-24" @default.
- W2383336334 title "Effects of different doses of valsartan on intrarenal Ang,ET and TGF-β1 in diabetic rats" @default.
- W2383336334 hasPublicationYear "2007" @default.
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