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- W2383345534 abstract "Objective To investigate the metabolic changes of DNA synthesis induced by the change of hydration status within hepatic cells under aniso osmotic conditions.Methods Incorporation rates of leucin into protein and TdR into DNA and the activities of ALT、AST and LDH in the supernatant of cell culture were observed. Results The cells were cultured for 120 minutes, the incorporation rates of leucine and TdR in the hepatocytes of the hyper osmotic group decreased 72.99% and 65.70% respectively as compared with those of the normo osmotic group( P 0.001), and they were 15.94% and 10.41% in the hypo osmotic group ( P0.05 ). The two incorporation rates were highly correlated in all the hypo 、hyper and normo osmotic groups. The activities of ALT、AST and LDH in the supernatant of cell cultures were within normal range.Conclusions These results indicate that the change of hepatocellular hydration status can regulate the DNA and the protein synthesis. This regulation may be one of the physiological factors to modulate cellular metabolism and the tolerance of hepatocytes to hypo osmotic environment which is greater than that to hyper osmotic one." @default.
- W2383345534 created "2016-06-24" @default.
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- W2383345534 date "2000-01-01" @default.
- W2383345534 modified "2023-09-24" @default.
- W2383345534 title "Hepatocellular hydration state on the modulation of DNA metabolism in rat hepatocyte" @default.
- W2383345534 hasPublicationYear "2000" @default.
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