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- W2383349937 abstract "Development of lymphoid tissue is determined by interactions between stromal lymphoid tissue organiser (LTo) and hematopoietic lymphoid tissue inducer cells. A failure for LTo to receive appropriate lymphotoxin engagement during embryogenesis leads to a complete cessation of lymph node and Peyer’s patch development. This identifies LTo as a key stromal population for lymphoid tissue organogenesis. However, little is known about the equivalent stromal cells that induce spleen development. In order to identify cell populations that specifically drive spleen organogenesis, a model for spleen tissue regeneration involving cell aggregate graft construction and transplantation was developed. Dissociation of neonatal murine spleen stromal tissue into a single cell suspension, followed by aggregation over collagen sheets and transplantation under the kidney capsule of adult mouse recipients, led to the induction of spleen tissue regeneration in a highly reproducible manner. By manipulating the cell input of graft aggregates, a spleen stromal organiser cell-type critical for spleen tissue formation was identified. We now demonstrate that spleen regeneration from neonatal tissue is governed by a lineage of CD45-MAdCAM-1+CD31+CD201+ stromal cells, distinct from previously reported mesenchymal organisers directing lymph node development." @default.
- W2383349937 created "2016-06-24" @default.
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- W2383349937 date "2015-09-01" @default.
- W2383349937 modified "2023-10-17" @default.
- W2383349937 title "A stromal organiser cell that directs neonatal spleen regeneration" @default.
- W2383349937 doi "https://doi.org/10.1016/j.exphem.2015.06.265" @default.
- W2383349937 hasPublicationYear "2015" @default.
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