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- W2383367429 abstract "Liver X receptor(LXR)is a member of the nuclear receptor superfamily of ligand-activated transcription factors.LXRs exhibit regulatory effects on diverse physiological functions,ranging from cholesterol and lipid metabolism to anti-inflammation,hepatobiliary diseases,and steroid hormone biosynthesis and metabolism.miRNAs are endogenous non-coding RNAs found in eukaryotes.In mammalian cells,miRNAs usually inhibit target genes expression by splicing their target messenger RNA or blocking mRNA translations.In our present study,we found hsa-miR-206could interact with LXRα3′untranslated region through direct binding with its response element.hsa-miR-206inhibited cellular LXRαmRNA level and its regulatory functions.hsa-miR-206also abolished the induction on LXR target gene SCD-1 by LXR ligand GW3965treatment.Collectively,hsa-miR-206negatively regulated LXRαmRNA level and its regulatory function.Our findings provides new insight to the regulation on endogenous LXRαby a novel mechanism,which implies potential interventions on LXRαrelated physiological functions." @default.
- W2383367429 created "2016-06-24" @default.
- W2383367429 creator A5055777832 @default.
- W2383367429 date "2013-01-01" @default.
- W2383367429 modified "2023-10-03" @default.
- W2383367429 title "hsa-miR-206 Negatively Regulates Nuclear Receptor LXRαmRNA Expression" @default.
- W2383367429 hasPublicationYear "2013" @default.
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