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- W2383389455 abstract "Objective To optimize the preparation technology of baicalin-phospholipids complex(BPC) in situ nasal gel.Methods Key factors affecting the preparation technology of BPC in situ nasal gel,Poloxamer407(P407),Poloxamer188(P188),and polyethylene glycol 6000(PEG 6000) were studied using central composite design-response surface method(CCD-RSM) with gelation temperature as evaluation index.The correlation between preparation technology parameters and gelation temperature was analyzed to establish relative equation of preparation technology parameters and gelation temperature and the best preparation technology parameters using multivariate mathematical statistical moment model.Results BPC(1.0 g) was dissolved in 0.1% triethylamine solution,then P407(18 g),P188(6 g),PEG 6000(1 g),glucose(5 g),BKC(0.02 g),and deionized water were added to reach 100 g.The mixture was uniformly dispersed in ice bath(4 ℃) under magnetic stirring and then was stored at 4 ℃ in refrigerator for more than 24 h until polymer was fully dissolved and clear solution was obtained.Conclusion The preparation technology of BPC in situ nasal gel by CCD-RSM is stable and suitable for industry." @default.
- W2383389455 created "2016-06-24" @default.
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- W2383389455 date "2012-01-01" @default.
- W2383389455 modified "2023-09-24" @default.
- W2383389455 title "Optimization for preparation technology of baicalin-phospholipid complex in situ nasal gel by central composite design-response surface method" @default.
- W2383389455 hasPublicationYear "2012" @default.
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