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- W2383397139 abstract "Objective To investigate the effects of Ulinastatin for circulatory function of patients with severe sepsis. Methods Severe sepsis patients over 18 years old admitted to the ICU in the First People's Hospital of Foshan City from October 2010 to December 2012 were selected and divided into Ulinastatin treatment group and control group. The patients in the control group were treated with classical SSC therapy, the patients in the treatment group were treated with the Ulinastatin [10 000-20 000 U/(kg·d)]. The changes of organ function and SOFA score were recorded before and after treatment. Results Compared to the control group, the arterial lactate of treatment group was significantly lower after treatment for 24 h, and diastolic blood pressure was significantly increased after treatment for 72 h(P 0.05). After treatment for 3 d, the levels of ALT and AST of Ulinastatin treatment group were significantly lower than those of the control group(P 0.05); after treatment for 3 d and 7 d, serum creatinine and SOFA score was lower than the control group over the same period, oxygenation index was higher, but the differences were not statistically significant(P 0.05). Conclusion Ulinastatin therapy can effectively improve the circulatory function and liver function in patients with severe sepsis. Ulinastatin therapy may also have a protective effective on the lung and kidney function." @default.
- W2383397139 created "2016-06-24" @default.
- W2383397139 creator A5034707576 @default.
- W2383397139 date "2013-01-01" @default.
- W2383397139 modified "2023-09-28" @default.
- W2383397139 title "A prospective randomized controlled study of Ulinastatin in improving organ function in patients with severe sepsis" @default.
- W2383397139 hasPublicationYear "2013" @default.
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