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- W2383407816 abstract "Objective To study regulation of HLA-DRB allele on immunoreaction in atopic dermatitis. Methods Polymerase Chain Reaction-Sequence Specific Primer(PCR-SSP) was used to classify the HLA-DRB allele. Radioallergosorbent Test(RAST) was used to test the serum sIgE. Results The DR3 frequency of extrinsic type of pure AD(EAD)group was higher than that of the control P 0.05RR is 5.27 however the DR6 frequency was lower than that of the control P 0.05 RR is 0.10. There was no significance between instrinsic type of pure AD(IAD) and the control. The 10 specimens of HLA-DR3 positive patients included one anti-h1 sIgE one anti-d1 sIgE seven anti-d2 sIgE two anti-mx2 sIgE and two anti-fx5E sIgE positive respectively. The comparison between DR3 and anti-d2 sIgE was significant P 0.05. Conclusion HLA-DR3 could be the susceptible gene of AD while HLA-DR6 could be the resistant gene of AD. The results indicate that people with HLA-DR3 are reliable to AD while people with HLA-DR6 are not. It is suggested that the specific immunoreactivity to mite which is induced by the AD patients with HLA-DR3 might trigger the pathogenesis of AD." @default.
- W2383407816 created "2016-06-24" @default.
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- W2383407816 date "2005-01-01" @default.
- W2383407816 modified "2023-09-23" @default.
- W2383407816 title "The Regulation of HLA-DR_3 Allele on Immunoreaction in Atopic Dermatitis" @default.
- W2383407816 hasPublicationYear "2005" @default.
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