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- W2383415077 abstract "To establish an HPLC and fluorescent detection method with N-(1-Pyrenyl) maleimide(NPM) as a pre-column derivatization reagent to determine N-acetylcysteine(NAC) in human plasma and study on its bioequivalence in Chinese healthy volunteers.The analytes were separated on a Diamonsil C18 column(5 μm ×150 mm ×4.6 mm) using 10 mmol·L-1 NaH2PO4 aqueous solution including 10 mmol·L-1 TMA and acetonitrile(50∶50) as a mobile phase at a flow rate The plasma concentration was determined by the method mentioned above.As a result the calibration curve was found to be linear over a range of 0.1-6.58 μg·mL-1,and the limit of the quantitation was 0.1 μg·mL-1.The recovery of the method ranged from 85.3%-103.3%.The coefficients of variation for inter-day and intra-day precisions were both15%.As an accurate,rapid and sensitive method,this assay has been successfully applied in the therapeutic drug monitoring,and the study of pharmacokinetic and bioavailability of NAC.The test preparation and the reference preparation are bioequivalence." @default.
- W2383415077 created "2016-06-24" @default.
- W2383415077 creator A5082835422 @default.
- W2383415077 date "2013-01-01" @default.
- W2383415077 modified "2023-09-23" @default.
- W2383415077 title "Determination of N-acetylcysteine in human plasma by precolumn derivatization and HPLC-FLD method and study on its bioequivalence" @default.
- W2383415077 hasPublicationYear "2013" @default.
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