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- W2383420121 abstract "OBJECTIVE:To retrospectively analyze the involved factor of radiation induced normal tissue late injury in long term survival patients with early stage nasopharyngeal carcinoma,and approach the improvement of conventional radiation technique to decrease the late complication.METHODS:The clinical data of 183 patients with stage Ⅰ/Ⅱ nasopharyngeal carcinoma undergone 6 MV-X ray radiotherapy from 03-06-2000 to 12-20-2002 were analyzed.Totally 103 patients were treated with facio-cervical portal and the other 80 patients were treated with pre-auricular portal.They all used tangential portal for neck irriadiation.The radiation doses of nasopharynx were ≤70 Gy delivered in 150 patients,while 70 Gy in 33 patients,and the medium dose was 70 Gy(64-82 Gy).The cervical lymphatic doses were ≤50 Gy delivered in 45 cases and 50 Gy in 138 cases,and the medium dose was 68 Gy(49-85 Gy).RESULTS:When the nasopharyngeal doses were prescribed≤70 Gy and 70 Gy,the frequencies of radiation induced late effects were showed below:xerostomia 91.3%(137/150) vs 100.0%(33/33);Trismus 48.0%(72/150) vs 81.8%(27/33).Radiation encephalopathy 14.7%(22/150) vs 36.4%(12/33);lower cranial neuropathy 17.3%(26/150) vs 42.4%(14/33).While the cervical doses were prescribed ≤50 Gy vs 50 Gy,the frequencies of late effeces were showed below:cervical subcutaneous fibrosis 22.2%(10/45) vs 63.8%(88/138);Lower cranial neuropathy 11.1%(5/45) vs 25.4%(35/138).The radiation dose was significantly positively correlated with the late effect rates.CONCLUSIONS:The dose distribution of two-portal radiation is unreasonable.It is the major cause of severe normal tissue late effects after radiotherapy in early stage nasopharyngeal carcinoma.The application of afterloading brachytherapy,anterior portal and anterior facio-cervical three-portal radiation technique may helpfully reduce the injury incidence of organs-at-risk." @default.
- W2383420121 created "2016-06-24" @default.
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- W2383420121 date "2010-01-01" @default.
- W2383420121 modified "2023-09-27" @default.
- W2383420121 title "Clinical analysis of radiation induced late injury in patients with prometaphase nasopharyngeal carcinoma" @default.
- W2383420121 hasPublicationYear "2010" @default.
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