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- W2383425706 abstract "Objective To study the changes of T-lymphocytes subsets and NK cells in patients with lung cancer before and after bronchical artery infusion chemotherapy(BAI) and evaluate their clinical significance.Methods 30 cases of lung cancer patients were enrolled in the study.APAAP techniques was used to measure T-lymphocytes subsets and NK cells in peripheral blood respectively before BAI,two weeks after BAI and four weeks after BAI and compared them with that of 30 health controls.Results The findings showed that the percentages of CD8+ cells in patients were significantly higher than that in health controls.However,percentages of CD3+ cells,CD4+cells,ratio of CD4+/CD8+ and the level of NK cells in patients were remarkably lower than that of health controls(P0.01).Two weeks after BAI,the T-lymphocytes subsets and the level of NK cells had no significant changes(P0.05).But the percentages of CD8+ cells significantly decreased,the percentages of CD3+ cells,CD4+cells,ratio of CD4+/CD8+ and the level of NK cells increased at four weeks after BAI.Conclusion The immune status in patients with lung cancer is compromised compared with the healthy controls.Application of BAI may restore immune function to a certain extent at four weeks after treatment.So clinical observation to the immunity of the patients with lung cancer has certain surveilant function on the treatment and prognosis of the lung cancer.It is reasonable that lung cancer patients receive the second BAI at four weeks after the first management." @default.
- W2383425706 created "2016-06-24" @default.
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- W2383425706 date "2011-01-01" @default.
- W2383425706 modified "2023-10-03" @default.
- W2383425706 title "Changes of T-lymphocytes subsets and NK cells in patients with lung cancer before and after bronchical artery infusion chemothery" @default.
- W2383425706 hasPublicationYear "2011" @default.
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