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- W2383426106 abstract "Objective To assess the relationship between XPC polymorphism (XPC-PAT) and susceptibility to colorectal cancer in chinese population. Methods Genotypes were determined by PCR methods in 150 healthy controls and 120 patients with colorectal cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression. Results The distribution of XPC-PAT genotypes among controls was LL 12.0%, LS 47.3%, SS 40.7%, respectively. The frequencies of the 3 genotypes among colorectal cancer cases were LL 5.8%, LS 38.4%, SS 58.8%, respectively. Individuals carrying LL genotype were at a decreased risk for colorectal cancer compared with those with the SS (adjusted OR 0.40, 95%CI = 0.18～0.99). Conclusions Our findings indicate that the Poly(AT) polymorphism in the XPC locus is associated with increased risk of colorectal cancer in chinese population." @default.
- W2383426106 created "2016-06-24" @default.
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- W2383426106 date "2009-01-01" @default.
- W2383426106 modified "2023-09-23" @default.
- W2383426106 title "XPC-PAT polymorphism and genetic predisposition to colorectal cancer" @default.
- W2383426106 hasPublicationYear "2009" @default.
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