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- W2383431372 abstract "OBJECTIVE To study the effects of different triptolide formulations given by micro electro mechanical systems(MEMS) micro-needles on skin injury of rheumatoid arthritis rats.METHODS Three formulations of triptolide were prepared including the aqueous solution of 20% propylene glycol,liposomes,and liposomes hydrogel patch.Rats with rheumatoid arthritis induced by collagen II were used,and 100 and 200 μm MEMS micro-needles treatment was performed on left and right sides of rat skin.The lactate dehydrogenase(LDH) activities were measured by ultraviolet spectro-photometric method.RESULTS After processed by MEMS micro-needle,the LDH activities of RA rat skin did not change obviously(P0.05).All triptolide formulations increased LDH activities(P0.05),and the increasement of solution group was largest(P0.001),followed by lipsomes group(P0.01) and liposomes hydrogel patch(P0.05).Nevertheless,there was no significant difference between left and right sides of rat skin(P0.05).CONCLUSION Both 100 and 200 μm MEMS micro-needles were safe for enhancement of transdermal delivery in rheumatoid arthritis rats.The skin injury was observably relieved when triptolide was prepared as liposomes hydrogel patch which is a perfect formulation for transdermal delivery of triptolide." @default.
- W2383431372 created "2016-06-24" @default.
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- W2383431372 date "2012-01-01" @default.
- W2383431372 modified "2023-09-26" @default.
- W2383431372 title "Effects of Different Triptolide Formulations Given by MEMS Micro-Needles on Skin Injury of Rheumatoid Arthritis Rats" @default.
- W2383431372 hasPublicationYear "2012" @default.
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