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- W2383439086 abstract "Objective To study the effect of taurine on basal forebrain choline acetyltransferase positive cells of rats induced by MnCl2·4H2O.Methods SPF SD rats were randomly assigned into 5 groups: Control,MnCl2-treatedⅠgroup,MnCl2-treatedⅡgroup,Taurine-prevented group and Taurine-treated group respectively.Water Morris Maze is utilized to probe rats learning and memory capacity after 8 weeks injection.Morphological change and number of ChaT positive neurons from basal forebrain were observed under Nikon microscope after immunohistochemistry.Results The average escapes latencies in both taurine-prevented and taurine-treated are evidently shorter than those in MnCl2-treated(P0.05).The probing times in taurine-prevented is obviously increase than that in MnCl2-treated Ⅰgroup(P0.05).There is no significance defference between taurine-treated and MnCl2-treated Ⅱgroup.The ChaT positive neurons number of basal forebrain vDB/hDB in MnCl2-treated group is less than that in control group(P0.05).Taurine-prevented reverse distinctly hDB ChaT number induced by MnCl2(P0.05).The vDB ChaT positive neurons number in taurine-treated is markedly less than that in MnCl2-treated Ⅱgroup(P0.05).Conclusion Taurine-prevented and taurine-treated can improve impaired memory and study capacity induced by Sub-chronic MnCl2 administration.Taurine-prevented may reverse markedly decreased hDB ChaT positive neurons of basal forebrain induced by MnCl2.However,It can't be detected in taurine-treated group." @default.
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- W2383439086 date "2011-01-01" @default.
- W2383439086 modified "2023-09-23" @default.
- W2383439086 title "The effect of taurine on basal forebrain ChaT neurons of rats induced by sub-chronic MnCl_2·4H_2O" @default.
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