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- W2383444587 abstract "Objective:To explore the changes of Tyrosine hydroxylase(TH)in dopaminergic neurons and nerve fibers in brain concussion(BU)rats.Methods:Animal model of concussive brain injury in rats was duplicated with a metallic pendulum-striker concussive device.BC rats were equally divided into 6 groups(n=12):day 1,2, 4,8,16,and 24 post-concussive injury groups.There were 12 normal rats in control group.The changes of do- paminergic neurons in substantia nigra pars compact(SNC)and ventral tegmental area(VTA)of midbrain,do- paminergic nerve fibers in caudate putamen of basal ganglia were studied by immunohistochemistry and image a- nalysis.Results:TH-immunoreaction(TH-IR)increased significantly in the SNC,VTA and basal ganglia on 1,4, 8,16 day post-concussive injury.The most significant change occured in 4 day group.The expression of TH-IR recovered in day 24 group in SNC and basal ganglia,but the TH-IR was still significantly higher as compared to the control group in VTA.Conclusion:The increased expression of TH-IR in dopaminergie neurons and nerve fi- bers in earlier period following BC may be caused by neuronal transient over excitation following post brain con- cussion.The increase in TH maintains for a period of time,which may reflect a compensatory response of dopam- inergic neurons to upregulate their synthesizing capacity." @default.
- W2383444587 created "2016-06-24" @default.
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- W2383444587 date "2006-01-01" @default.
- W2383444587 modified "2023-09-25" @default.
- W2383444587 title "Influence of brain concussion on dopaminergic neuron and nerve fiber in rats" @default.
- W2383444587 hasPublicationYear "2006" @default.
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