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- W2383445306 abstract "Objective:To investigate the antimicrobial effect of the venous catheters coated with chlorhexidine and polyurethanein which were made in our laboratory.Methods:A series of antimicrobial tests were carried out: (1) Determination of the minimum inhibitory concentration (MIC) of the coating solution; (2) Observation of the antimicrobial activity in vitro; (3) Observation of antimicrobial durability; (4) Observation of the effect of high temperature on antimicrobial activity of the coated catheters; (5) Determination of antimicrobial effect of the coated catheters in experimental animal. Results:The MIC 90 and MIC 50 of the coating solution for saukeus were 8.5 μg/ml and 2.8 μg/ml, respectively, while those for P·aeruginosa were 31.3 μg/ml and 15.6 μg/ml. Again, the coated catheters produced inhibitory zones on the blood agar plates. In contrast, uncoated catheters produced no inhibitory zone. The mean days of antimicrobial activity of the coated catheters against S·aureus, P·aeruginosa, and Escheri Chiacoli were 15.6±0.6, 3.0±0.4, and 3.6±0.2, respectively. Antimicrobial activity of the coated catchers treated with high temperature was not different from that of normal coated catheters. After hidden under rabbit′s skin for 4 days, the histological examination revealed that the subcutaneous tissues around the coated catheters were clear and had less inflammatory substances. In contrast, the tissues around uncoated catheters showed significant pathologic changes with more inflammatory substances. Conclusion: Those results prove that the coated catheter has powerful antimicrobial activity." @default.
- W2383445306 created "2016-06-24" @default.
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- W2383445306 date "2001-01-01" @default.
- W2383445306 modified "2023-09-25" @default.
- W2383445306 title "Preliminary Studies on the Antimicrobial Venous Catheters" @default.
- W2383445306 hasPublicationYear "2001" @default.
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