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- W2383454639 abstract "Objective: To evaluate the cytotoxicity,biocompatibility and biological safety of composite materials of tracheal prosthesis in vitro , providing scientific basis for clinical application.Methods: According to standard of ISO10993 1:1992 documents,the cellular cultivation and cytotoxicity test in vitro were conducted to evaluate the composite materials influence on the morphology,growth and proliferation of cultured cells. The hemolysis test was done to assess the impact on the function and metabolism of erythrocyte.Moreover, the acute systemic toxicity test,sensitivation test and pyrogen test were also performed. Results:(1)There was no obvious changes in cultured cells attachment to the surface of the composite materials;(2)The growth and proliferation of the cultured cells was not significantly inhibited by the composite materials;(3)The composite materials had no hemolytic reation and their hemolysis rates were no more than 5%;(4)It had no acute systemic toxicity,no sensitivity,and no pyrogen reaction in vitro .Conclusion:The composite materials of tracheal prosthesis have excellent biocompatibility and biological safety for the clinical application in the future." @default.
- W2383454639 created "2016-06-24" @default.
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- W2383454639 date "2002-01-01" @default.
- W2383454639 modified "2023-09-25" @default.
- W2383454639 title "In vitro toxicology and biocompatibility of composite materials of tracheal prosthesis" @default.
- W2383454639 hasPublicationYear "2002" @default.
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